Free Kappa and Lambda Light Chains in Plasma Cell Dyscrasias
نویسندگان
چکیده
منابع مشابه
kappa/lambda index for confirming urinary free light chain in amyloidosis AL and other plasma cell dyscrasias.
Primary systemic amyloidosis (AL), a disease involving the deposition of immunoglobulin light chains in tissue, is caused by a plasma cell dyscrasia. In the case of amyloidosis reported here, no monoclonal component was seen upon routine protein electrophoresis of serum or urine nor was a bone marrow analysis positive for AL. Immunofixation electrophoresis did not show a typical paraprotein ban...
متن کاملBiphenotypic plasma cell myeloma: two cases of plasma cell neoplasm with a coexpression of kappa and lambda light chains.
UNLABELLED Plasma cell neoplasm (PCM) is a medullary and extra medullary proliferation of clonal plasma cells that occurs due to accidental translocation of proto-oncogenes into immunoglobulin (Ig) gene loci. While the majority of plasma cell neoplasms are monoclonal, up to 2% of the PCMs [1] considered being biclonal based on electrophoretic analysis, characterized by secretion of paraprotein ...
متن کاملReference values for immunoglobulin kappa and lambda light chains and the kappa/lambda ratio in children's serum.
We analyzed 708 serum samples from healthy children and adolescents by immunonephelometry to obtain reference values for the immunoglobulin kappa (kappa) and lambda (lambda) light chains and for their ratio at a time of life when immunoglobulin synthesis is maturing and continually being stimulated. The lambda chain concentration that is to be maintained throughout the child's life is reached v...
متن کاملResponse to therapy in IgG myeloma patients excreting lambda or kappa light chains: CALGB experience.
Sixty-eight previously untreated patients with IgG myeloma who were entered into five protocols of Cancer and Leukemia Group B (CALGB) were studied in order to determine the possible influence of excretion of kappa versus lambda urinary light chains on responses to treatment and survival. All patients in these protocols were included if the serum and urine protein abnormalities were confirmed b...
متن کاملComparing domain interactions within antibody Fabs with kappa and lambda light chains
IgG antibodies are multi-domain proteins with complex inter-domain interactions. Human IgG heavy chains (HCs) associate with light chains (LCs) of the κ or λ isotype to form mature antibodies capable of binding antigen. The HC/LC interaction involves 4 domains: VH and CH1 from the HC and VL and CL from the LC. Human Fabs with κ LCs have been well characterized for their unfolding behaviors and ...
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ژورنال
عنوان ژورنال: Proceedings of Singapore Healthcare
سال: 2011
ISSN: 2010-1058,2059-2329
DOI: 10.1177/201010581102000111